Publications

原著論文

• Takeda Y, Chinen T*, Honda S, Takatori S, Okuda S, Yamamoto S, Fukuyama M, Takeuchi K, Tomita T, Hata S* and Kitagawa D*. (2024)
• Molecular basis promoting centriole triplet microtubule assembly
• Nature Communications, DOI: 10.1038/s41467-024-46454-x (*corresponding authors) (Press release: https://www.u-tokyo.ac.jp/content/400235656.pdf)

• Ito K*., Tsuruoka Y*. and Kitagawa D*. (2024)
• Predicting potential target genes in molecular biology experiments using machine learning and multifaceted data sources
• iScience, DOI: 10.1016/j.isci.2024.109309 (*corresponding authors)

• #Harada T., #Hata S*., Takagi R., Komori T., Fukuyama M., Chinen T.and Kitagawa D*. (2023)
• An antioxidant screen identifies ascorbic acid for prevention of light-induced mitotic prolongation in live cell imaging
• Communications Biology, DOI: 10.1038/s42003-023-05479-6 (*corresponding authors, # co-first authors)

• #Mabuchi A., #Hata S*., Genova M., Tei C., Ito K., Hirota M., Komori T., Fukuyama M., Chinen T., Toyoda A. and Kitagawa D*. (2023)
• ssDNA is not superior to dsDNA as long HDR donors for CRISPR-mediated endogenous gene tagging in human diploid RPE1 and HCT116 cells
• BMC Genomics, DOI: 10.1186/s12864-023-09377-3 (*corresponding authors, # co-first authors)

• #Komori T., #Hata S*., Mabuchi A., Genova M., Harada T., Fukuyama M., Chinen T. and Kitagawa D*. (2023)
• A CRISPR-del-based pipeline for complete gene knockout in human diploid cells
• Journal of Cell Science, DOI: 10.1242/jcs.260000 (*corresponding authors, # co-first authors)

• Tanaka A., Nakano T., Watanabe K., Masuda K., Honda G., Kamata S., Yasui R., Kozuka-Hata H., Watanabe C., Chinen T., Kitagawa D., Sawai S., Oyama M., Yanagisawa M. and Kunieda T*. (2022)
• Stress-dependent cell stiffening by tardigrade tolerance proteins that reversibly form a filamentous network and gel
• PLOS Biology, DOI: 10.1371/journal.pbio.3001780 (*corresponding authors)

• Yamamoto S., Yabuki R. and Kitagawa D*. (2021)
• Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis
• Biology Open, DOI: 10.1242/bio.056432 (*corresponding authors)

• #Ito K., #Watanabe K., Ishida H., Matsuhashi K., Chinen T., Hata S. and Kitagawa D*. (2021)
• Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle
• Journal of Cell Biology, DOI: 10.1083/jcb.202005153 (*corresponding authors, # co-first authors)

• #Chinen T*., #Yamazaki K., Hashimoto K., Fujii K., Watanabe K., Takeda Y., Yamamoto S., Nozaki Y., Tsuchiya Y., Takao D. and Kitagawa D*. (2021)
• Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly
• Journal of Cell Biology, DOI: 10.1083/jcb.202006085 (*corresponding authors, # co-first authors)

• Takeda Y., Yamazaki K. Hashimoto K. Watanabe K. Chinen T*. and Kitagawa D*. (2020)
• The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression
• Journal of Cell Science, DOI: 10.1242/jcs.241281 (*corresponding authors)

• Chinen T., Yamamoto S. Takeda Y. Watanabe K. Kuroki K. Hashimoto K. Takao D. and Kitagawa D*. (2020)
• NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells.
• The EMBO Journal, DOI: 10.15252/embj.2019102378 (*corresponding authors)

• Takao D*., Watanabe K., Kuroki K. and Kitagawa D*. (2019)
• Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation.
• Biology Open, DOI: 10.1242/bio.047175 (*corresponding authors)

• Takao D*., Yamamoto S. and Kitagawa D*. (2019)
• A Theory of Centriole Duplication Based on Self-Organized Spatial Pattern Formation.
• Journal of cell biology, DOI: 10.1083/jcb.201904156 (*corresponding authors)

• Yoshiba S., Tsuchiya Y., Ohta M., Gupta A., Shiratsuchi G., Nozaki Y., Ashikawa T., Fujiwara T., Natsume T., Kanemaki M. and Kitagawa D*. (2019)
• HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates.
• Journal of cell science, doi: 10.1242/jcs.217521 (*corresponding authors)

• Yamamoto S. and Kitagawa D*. (2019)
• Self-organization of Plk4 regulates symmetry breaking in centriole duplication.
• Nature Communications, doi: 10.1038/s41467-019-09847-x (*corresponding authors)
• 詳細はこちら(日本語要旨)

• Watanabe K., Takao D., Ito K., Takahashi M. and Kitagawa D*. (2019)
• The Cep57-pericentrin module organizes PCM expansion and centriole engagement.
• Nature Communications, doi: 10.1038/s41467-019-08862-2. (*corresponding authors)
• 詳細はこちら(日本語要旨)

• Ohta M., Watanabe K., Ashikawa T., Nozaki Y., Yoshiba S., Kimura A. and Kitagawa D*. (2018)
• Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number.
• Cell Reports, 23, 3160-3169, doi: 10.1016/j.celrep.2018.05.030. (*corresponding authors)

• #Okamoto N*., #Tsuchiya Y., Miya F., Tsunoda T., Yamashita K., Boroevich KA., Kato M., Saitoh S., Yamasaki M., Kanemura Y., Kosaki K. and Kitagawa D.* (2017)
• A novel genetic syndrome with STARD9 mutation and abnormal spindle morphology.
• Am J Med Genet A, doi: 10.1002/ajmg.a.38391. (*corresponding authors, # co-first authors)

• Gupta A., Tsuchiya Y., Ohta M., Shiratsuchi G. and Kitagawa D*. (2017)
• NEK7 is required for G1 progression and procentriole formation.
• Molecular Biology of the Cell, 28, 2123-2134. (*corresponding authors)

• #Okamoto N*., #Tsuchiya Y., Kuki I., Yamamoto T., Saitsu H., Kitagawa D.* and Matsumoto N.* (2017)
• Disturbed chromosome segregation and multipolar spindle formation in a patient with CHAMP1 mutation.
• Molecular Genetics and Genomic Medicine, 5, 585-591 (*corresponding authors, # co-first authors)

• Jin M., Pomp O., Shinoda T., Toba S., Torisawa T., Furuta K., Oiwa K., Yasunaga T., Kitagawa D., Matsumura S., Miyata T., Tan T.T., Reversade B*. and Hirotsune S*. (2017)
• Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.
• Scientific Reports, 12, 739902. doi: 10.1038/srep39902. (*corresponding authors)

• Tsuchiya Y., Yoshiba S., Gupta A., Watanabe K. and Kitagawa D*. (2016)
• Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.
• Nature Communications, doi: 10.1038/ncomms12567 (*corresponding authors)

• Matsuura R., Ashikawa T., Nozaki Y. and Kitagawa D*. (2016)
• LIN-41 inactivation leads to delayed centrosome elimination and abnormal chromosome behavior during female meiosis in Caenorhabditis elegans.
• Molecular Biology of the Cell, 27, 799-811 (*corresponding authors)

• Zitouni S*., Francia M.E*., Leal F., Montenegro Gouveia S., Nabais C., Duarte P., Gilberto S., Brito D., Moyer T., Kandels-Lewis S., Ohta M., Kitagawa D., Holland A.J., Karsenti E., Lorca T., Lince-Faria M. and Bettencourt-Dias M*. (2016)
• CDK1 prevents unscheduled PLK4-STIL complex assembly in centriole biogenesis.
• Current Biology, 26, 1127-37 (*corresponding authors)

• Shiratsuchi G., Takaoka K., Ashikawa T., Hamada H. and Kitagawa D*. (2015)
• RBM14 prevents assembly of centriolar protein complexes and maintains spindle integrity.
• EMBO J., 34, 97-114 (*corresponding authors)

• Shiratsuchi G. and Kitagawa D*. (2015)
• Suppression of the ectopic assembly of centriole proteins ensures mitotic spindle integrity.
• Molecular and Cellular Oncology, DOI: 10.1080/23723556.2014.1002717 (*corresponding authors)

• Ohta M., Ashikawa T., Nozaki Y., Kozuka-Hata H., Goto H., Inagaki M., Oyama M. and Kitagawa D*. (2014)
• Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole.
• Nature Communications, DOI: 10.1038/ncomms6267 (Open access) (*corresponding authors)

• Kitagawa D., Kohlmaier G., Keller D., Strnad P., Balestra F.R., Flückiger I. and Gönczy P*. (2011)
• Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL.
• J. Cell Sci., 124, 3884-3893 (*corresponding authors)

• Kitagawa D., Vakonakis I., Olieric N., Hilbert M., Keller D., Olieric V., Bortfeld M., Erat M.C., Flückiger I., Gönczy P*. and Steinmetz M.O. (2011)
• Structural basis of the 9-fold symmetry of centrioles.
• Cell, 144, 364-375 (*corresponding authors)

• Kitagawa D., Flückiger I., Polanowska J., Keller D., Reboul J. and Gönczy P*. (2011)
• PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos.
• Developmental Cell, 20, 550-562 (*corresponding authors)

• Kitagawa D., Busso C., Flückiger I. and Gönczy P*. (2009)
• Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos.
• Developmental Cell, 17, 900-907 (*corresponding authors)

• (You can find other papers in Pubmed)

総説

• 伊藤慶, 鶴岡慶雅, 北川大樹 (2022)
• 任意のヒト遺伝子に関わる生命科学実験の検索・提案ウェブツール「LEXAS」
• 実験医学, vol. 41, No.1, 102-108

• 新倉竜太, 知念拓実 (2022)
• CRISPRスクリーニングデータベースを活用した創薬標的探索
• 生物工学会誌, 第100巻, 第8号, 449. 2022; DOI: 10.34565/seibutsukogaku.100.8_449

• 竹田穣, 知念拓実, 北川大樹 (2022)
• 中心体タンパク質による分裂期PLK1制御を介した適切な細胞分裂保証メカニズム
• 生化学, 6月号掲載, vol.94, No.3 2022, 419-422

• Takumi K. and Kitagawa D. (2022)
• Experimental and Natural Induction of de novo Centriole Formation
• Frontiers in Cell and Developmental Biology, DOI: 10.3389/fcell.2022.861864

• 北川大樹 (2022)
• 中心体
• 遺伝学の百科事典・継承と多様性の源, 日本遺伝学会編, p178-179

• 馬渕陽, 畠星治, 北川大樹 (2021)
• 相分離を介した中心体の制御機構
• 実験医学増刊, vol.39, No.10, 110-115

• Yamamoto S. and Kitagawa D. (2020)
• Emerging insights into symmetry breaking in centriole duplication: updated view on centriole duplication theory
• Current Opinion in Structural Biology 2021, 66:8–14, doi:10.1016/j.sbi.2020.08.005

• 松橋恭平, 北川大樹 (2020)
• 中心体の構造と細胞分裂
• 生体の科学, 2020 7月号掲載, vol. 71 No.4 338-342

• Takeda Y., Kuroki K., Chinen T. and Kitagawa D. (2020)
• Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes
• CELL STRUCTURE AND FUNCTION 45: 57–64 (2020), doi:10.1247/csf.20007

• Hashimoto K., Chinen T. and Kitagawa D. (2020)
• Mechanisms of spindle bipolarity establishment in acentrosomal human cells
• MOLECULAR & CELLULAR ONCOLOGY 2020, VOL. 7, NO. 3, e1743899, doi:10.1080/23723556.2020.1743899

• Ito K., Watanabe K., and Kitagawa D., (2020)
• The Emerging Role of ncRNAs and RNA-Binding Proteins in Mitotic Apparatus Formation
• Non-Coding RNA 2020, 6(1), 13; doi:10.3390/ncrna6010013

• 竹田穣, 知念拓実, 北川大樹 (2019)
• 分裂期紡錘体形成を阻害する抗がん薬開発の動向
• ファルマシア, 10月号掲載, Vol.55 No.10 2019. 954-958

• Gupta A. and Kitagawa D. (2018)
• Ultrastructural diversity between centrioles of eukaryotes.
• Journal of Biochemistry, 164, 1-8, doi: 10.1093/jb/mvy031.

• 北川大樹 (2017)
• 進化的に保存された中心体の複製と成熟過程の分子機構
• 生化学, ８月号掲載, vol. 89, No.4, 489-497

• 北川大樹 (2013)
• 中心小体構築と複製の分子メカニズム
• 細胞工学, vol. 32, No.3, 285-290

• 北川大樹 (2012)
• 中心小体複製の分子機構
• 生化学, ２月号掲載

• 北川大樹 (2011)
• 中心小体再構成のスナップショット
• 細胞工学, vol. 30, No.11, 1127

• 北川大樹, Michel O. Steinmetz, and Pierre Gönczy (2011)
• 中心小体複製開始の分子メカニズム
• 実験医学, vol. 29, No.11, 1777-1780  

• 北川大樹, Michel O. Steinmetz, and Pierre Gönczy (2011)
• 進化上保存された中心小体の９回対称構造の謎を解く
• 細胞工学, vol. 30, No.5, 534-5